Back

Genetic Prediction of Circulating Lipoprotein(a) Levels in Diverse Populations

2026-02-22 cardiovascular medicine Title + abstract only
View on medRxiv
Show abstract

BackgroundCirculating lipoprotein(a) [Lp(a)] levels are highly heritable and linked to atherosclerotic cardiovascular disease, yet clinical measurement rates remain low (<1%) in the United States. The high heritability of Lp(a) across populations makes genetic prediction an attractive approach for closing this testing gap, but existing polygenic scores transfer poorly across populations. Haplotype-based prediction models, which use standard genome-wide genotype data to capture common-, rare-, an...

Predicted journal destinations

1
Circulation: Genomic and Precision Medicine
30 training papers
Top 0.3% 14.3%
2
Circulation
37 training papers
Top 0.6% 11.5%
3
Journal of the American Heart Association
92 training papers
Top 4% 8.8%
4
Nature Communications
483 training papers
Top 16% 6.3%
5
eLife
262 training papers
Top 5% 5.8%
6
Scientific Reports
701 training papers
Top 48% 5.8%
7
Atherosclerosis
16 training papers
Top 0.5% 4.1%
8
PLOS ONE
1737 training papers
Top 85% 4.1%
9
Frontiers in Cardiovascular Medicine
33 training papers
Top 5% 3.8%
10
Open Heart
18 training papers
Top 3% 3.1%
11
Hypertension
20 training papers
Top 1% 3.0%
12
PLOS Medicine
95 training papers
Top 3% 2.7%
13
BMC Medicine
155 training papers
Top 12% 1.9%
14
Nature Genetics
72 training papers
Top 7% 1.9%
15
European Heart Journal - Digital Health
15 training papers
Top 4% 1.3%
16
The American Journal of Cardiology
15 training papers
Top 5% 1.3%
17
BMJ Open
553 training papers
Top 60% 1.1%
18
Human Genetics and Genomics Advances
39 training papers
Top 6% 1.0%
19
The Journal of Clinical Endocrinology &amp; Metabolism
26 training papers
Top 2% 0.9%
20
Nature Medicine
88 training papers
Top 13% 0.9%
21
Heart Rhythm
16 training papers
Top 5% 0.9%
22
Human Molecular Genetics
28 training papers
Top 7% 0.9%
23
Genome Medicine
56 training papers
Top 8% 0.7%
24
Journal of Clinical Medicine
77 training papers
Top 24% 0.7%