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Building The Human Genotype-Phenotype Map to Harness Pleiotropy and Refine Disease Mechanisms
2026-02-20
genetic and genomic medicine
Title + abstract only
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Mapping the pleiotropic effect of genetic variation on biological processes and complex phenotypes is fundamental to extracting translational insight from genome-wide association studies (GWAS). Here we present The Human Genotype-Phenotype Map (GPMap), a repository of colocalizing genetic associations across 15,997 complex traits and 2.7 million molecular measurements, leveraging common and rare variants and cis-and trans-acting effects across disaggregated tissue types and single cell datasets ...
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