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Agentic Trial Emulation to Learn Health System-specific Drug Effects At Scale
2026-02-20
health informatics
Title + abstract only
View on medRxiv
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ObjectiveElectronic Health Record (EHR)-based trial emulation can support translation of randomized clinical trial (RCT) evidence into practice, yet emulations often diverge from published RCT results. We hypothesized that these discrepancies are structured and learnable properties of a health systems data-generating process, and that autonomous agentic workflows can generate discrepancies at the scale required for cumulative learning. Materials and MethodsWe developed an agentic trial emulatio...
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