Back

The impact of USAID and CDC funding cuts on HIV incidence and mortality in KwaZulu Natal, South Africa

Shenoi, S. V.; Moll, A. P.; Yoo, Y. R.; Zama, P.; George, G.; Morojele, N.; Mbaya, J.; Govender, K.; Sunpath, H.; Gasa, S.; De Wet, C.; Jeetoo, M.; Ndabandaba, T.; Charles, D.; Braithwaite, R. S.

2026-02-22 hiv aids
10.64898/2026.02.18.26346597 medRxiv
Show abstract

BackgroundAbrupt cessation of USAID and CDC resources to KwaZulu Natal province in South Africa, threatens the progress over decades to address HIV. MethodsWe used a previously developed validated HIV transmission model with input from the KZN Department of Health and local stakeholders to estimate impact of funding cuts on HIV incidence and mortality at 12-months and through 2030. We applied the model to estimate the impact of restoring funds on HIV incidence and mortality. ResultsHIV incidence increased at 12 months and through 2030 by 3.4% and 22.8%, leading to 35,300 and 116,100 additional infections, and 12,800 and 42,300 additional deaths, respectively. Restoring funding after a 12-month pause, reallocated to focus on long-acting PrEP, would avert 12,600 new infections. ConclusionThis model application demonstrates that the sudden cessation of USAID and CDC commitments in the largest HIV epidemic in the world leads to increased incidence and mortality and threatens decades of progress in KZN, South Africa. Restoring funding within 12 months and increasing efficiency of HIV interventions can reestablish KwaZulu Natal province, South Africas trajectory toward EHE goals.

Matching journals

The top 4 journals account for 50% of the predicted probability mass.

1
The Lancet Global Health
24 papers in training set
Top 0.1%
17.5%
2
PLOS ONE
4510 papers in training set
Top 16%
11.8%
3
PLOS Medicine
98 papers in training set
Top 0.1%
11.6%
4
AIDS
31 papers in training set
Top 0.1%
9.5%
50% of probability mass above
5
JAIDS Journal of Acquired Immune Deficiency Syndromes
19 papers in training set
Top 0.1%
8.6%
6
Journal of the International AIDS Society
20 papers in training set
Top 0.1%
5.9%
7
Clinical Infectious Diseases
231 papers in training set
Top 2%
3.4%
8
BMJ Global Health
98 papers in training set
Top 1%
3.1%
9
BMJ Open
554 papers in training set
Top 7%
2.9%
10
BMC Infectious Diseases
118 papers in training set
Top 2%
2.4%
11
PLOS Global Public Health
293 papers in training set
Top 3%
2.0%
12
AIDS and Behavior
14 papers in training set
Top 0.2%
2.0%
13
PLOS Computational Biology
1633 papers in training set
Top 17%
1.6%
14
The Journal of Infectious Diseases
182 papers in training set
Top 3%
1.6%
15
JAMA Network Open
127 papers in training set
Top 2%
1.6%
16
Nature Communications
4913 papers in training set
Top 56%
1.3%
17
Open Forum Infectious Diseases
134 papers in training set
Top 2%
0.9%
18
Infectious Diseases of Poverty
10 papers in training set
Top 0.3%
0.9%
19
Epidemics
104 papers in training set
Top 2%
0.8%
20
BMC Public Health
147 papers in training set
Top 6%
0.7%
21
American Journal of Epidemiology
57 papers in training set
Top 1%
0.7%
22
International Journal of Infectious Diseases
126 papers in training set
Top 4%
0.7%
23
BMC Health Services Research
42 papers in training set
Top 2%
0.7%
24
Nature Medicine
117 papers in training set
Top 6%
0.7%
25
Nature Human Behaviour
85 papers in training set
Top 5%
0.6%