Back

Anti-inflammatory effects of 12-HHT via epithelial barrier enhancement in colon organoids of normoganglionosis in Hirschsprungs disease

2026-02-19 gastroenterology Title + abstract only
View on medRxiv
Show abstract

PurposeHirschsprung-associated enterocolitis remains a major postoperative complication of Hirschsprungs disease (HD), and impaired epithelial barrier integrity has been proposed as a contributing factor. In this study, we investigated whether 12-hydroxyheptadecatrienoic acid (12-HHT), an endogenous leukotriene B4 receptor 2 (BLT-2) agonist, enhances the epithelial barrier and exerts anti-inflammatory effects in patient-derived colonic organoids. MethodsNormoganglionic specimens from rectal/rec...

Predicted journal destinations