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Seasonal vaccine-induced immunity shows preserved cross-reactivity to H3N2 subclade K in adults

Wilson, A.; Lerman, B.; Ramsamooj, R.; Mischka, J.; Ehrenhaus, J.; Aracena, A.; Figueroa, Y.; Farrugia, K.; Gonzalez-Reiche, A.; Nardulli, J.; Khalil, Z.; Gleason, C.; Hermann, E.; Srivastava_, K.; Sordillo, E. M.; van Bakel, H.; Abbad, A.; Krammer, F.; Simon, V.

2026-02-18 infectious diseases
10.64898/2026.02.18.26346502 medRxiv
Show abstract

AO_SCPLOWBSTRACTC_SCPLOWInfluenza A subclade K viruses caused high infection rates in the 2025/2026 Northern Hemisphere season, raising concerns about antigenic drift and reduced vaccine effectiveness. We measured antibody responses in matched human pre- and post-vaccination sera against a vaccine-like as well as subclade K isolates. Pre-existing immunity to subclade K variants was noted with seasonal influenza vaccination boosting titers two-fold against subclade K and three-fold against the vaccine-like strain, indicating little antigenic drift. These data contrast ferret-based predictions of marked antigenic drift.

Published in eBioMedicine (predicted rank #2) · training set

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.