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Genome-wide association studies to identify shared and distinct mechanisms of fibrosis across 12 organ-systems

2026-02-19 genetic and genomic medicine Title + abstract only
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IntroductionFibrosis can affect organs throughout the body and is present in a wide range of diseases. Recent research has suggested that there could be shared biological mechanisms that lead to fibrosis in different organs. MethodsWe performed genome-wide association studies using UK Biobank for fibrosis in 12 different organ-systems and meta-analysed results with previously published studies of fibrotic diseases. We considered genetic associations that colocalised across [≥]3 organs as tho...

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