Integrating Histologic Descriptors into the Ninth Edition TNM Staging Improves Prognostic Stratification of Lung Adenocarcinoma

2026-02-18 pathology Title + abstract only

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BackgroundHistologic descriptors such as lymphovascular invasion (LVI), visceral pleural invasion (VPI), spread through air spaces (STAS), and grading system have each been associated with adverse outcomes in lung adenocarcinoma (LUAD). However, with the exception of VPI, these features are not formally incorporated into the TNM staging system. We evaluated the prognostic value and incremental contribution of these histologic descriptors within the framework of the 9th edition TNM staging system...

Integrating Histologic Descriptors into the Ninth Edition TNM Staging Improves Prognostic Stratification of Lung Adenocarcinoma

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