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Household Transmission of Enterovirus D68 in Washington and Oregon, USA, 2022-2024

Roychoudhury, P.; Wetzler, E.; Elias-Warren, A.; Harteloo, A.; Kim, H. G.; Kong, K.; Xie, H.; Gov, J.; Mills, M. G.; Frivold, C.; Hollcroft, M.; Drummond, M.; Hatchie, T.; Clark, E.; Ehmen, B.; Han, P. D.; Gamboa, L.; Grindstaff, S.; Stone, J.; Greninger, A. L.; Starita, L. M.; Lockwood, C.; Englund, J. A.; Weil, A. A.; Reich, S. L.; Mularski, R. A.; Schmidt, M. A.; Kuntz, J. L.; Naleway, A. L.; Chu, H. Y.

2026-02-22 infectious diseases
10.64898/2026.02.16.26346322 medRxiv
Show abstract

Household transmission of EV-D68 was identified in 35 of 1040 households (3.4%) in the Pacific Northwest between 2022-2024, with an estimated secondary attack rate of 15%. Sequences from within households clustered closely with 0 to 2 pairwise nucleotide differences (median 1) between cases 6-14 days apart (median 7).

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