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Multi-tissue transcriptome-wide association study identifies 29 risk genes associated with attention-deficit/hyperactivity disorder
2026-02-22
genetic and genomic medicine
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BackgroundAttention-deficit/hyperactivity disorder (ADHD) is a common heritable neurodevelopmental disorder, affecting [~]7 million children (11.4%) in the U.S. However, ADHDs underlying genetic architecture remains largely unknown. Transcriptome-wide association studies (TWAS), which integrate expression quantitative trait loci (eQTL) and GWAS summary data, can identify differentially expressed risk genes underlying complex phenotypes. Here we conduct a TWAS of ADHD using expression data from m...
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