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Prognostic and Therapeutic Relevance of BRCA1/2 Zygosity in Prostate Cancer: A Multicohort Desk-Based Analysis

2026-02-16 oncology Title + abstract only
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IntroductionBRCA1/2 alterations are increasingly recognized as biologically and clinically relevant features in prostate cancer, yet the prognostic and therapeutic significance of zygosity status remains uncertain. Understanding differences between monoallelic and biallelic inactivation may refine risk stratification and guide therapeutic decision-making. Materials and MethodsA retrospective, desk-based observational analysis was performed using publicly accessible datasets from TCGA-PRAD (prim...

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