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Mindfulness-Oriented Recovery Enhancement rebalances prefrontal responses to drug and natural reward cues in opioid use disorder
2026-02-15
addiction medicine
Title + abstract only
View on medRxiv
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Despite decades of clinical implementation of medications for opioid use disorder (OUD), overdose mortality rates remain high, underscoring a critical gap in treatments that target brain mechanisms driving addiction. Mindfulness-Oriented Recovery Enhancement (MORE) has demonstrated efficacy in reducing opioid use and craving, hypothetically by restructuring the salience of drug and natural rewards. Yet, to date, MOREs neurobiological mechanisms remain unclear. In this first functional magnetic r...
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