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Cannabis Co-Use and Endocannabinoid System Modulation in Tobacco Use Disorder:A Translational Systematic Review and Meta-Analysis
2026-02-14
addiction medicine
Title + abstract only
View on medRxiv
Show abstract
Tobacco use disorder (TUD) remains a leading cause of preventable mortality, and existing pharmacotherapies yield 12-month abstinence rates below 30%. As cannabis legalization expands, approximately 18-22% of people who use tobacco report concurrent cannabis use, yet the impact of co-use on cessation outcomes and the therapeutic potential of endocannabinoid system (ECS) modulation remain unclear. We conducted a translational systematic review and meta-analysis following PRISMA 2020 guidelines, s...
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