A meta-analysis of clinically ascertained lipoedema cohorts from the UK and Spain identifies overlapping susceptibility loci with the UK Biobank

2026-02-12 genetic and genomic medicine Title + abstract only

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Lipoedema is a chronic adipose tissue disorder mainly affecting women with excess subcutaneous fat deposition on the lower limbs, associated with pain and tenderness. There is often a family history of lipoedema, suggesting a genetic origin, but the contribution of genetics is not well studied. We conducted a genome-wide association study (GWAS) for this disorder in a clinically ascertained cohort from Spain and performed a meta-analysis with the UK lipoedema cohort GWAS. We then used the result...

A meta-analysis of clinically ascertained lipoedema cohorts from the UK and Spain identifies overlapping susceptibility loci with the UK Biobank

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