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A custom phenotypic profile for Fanconi anemia: Addressing gaps in existing disease annotations
2026-02-12
genetic and genomic medicine
Title + abstract only
View on medRxiv
Show abstract
Fanconi anemia (FA) is a rare genetic disorder of impaired DNA repair characterized by progressive bone marrow failure, congenital malformations, and cancer predisposition. Early identification of individuals with FA is critical for timely clinical management, yet phenotype-driven approaches to FA identification are hindered by inconsistencies in existing phenotypic profiles. We compared the Human Phenotype Ontology (HPO) annotations for FA in OMIM (215 terms across 22 complementation group entr...
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