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Direct and Indirect Genetic Effects of Parental Liabilities to Mental Health Conditions and Related Traits on Children's Behavioural Difficulties: A Multi-Cohort Study
2026-02-12
psychiatry and clinical psychology
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BackgroundParental genetics matters for childrens behavioural difficulties, but the extent to which this is due to direct genetic transmission versus environmentally mediated indirect genetic effects remains unclear. MethodsWe studied eight European birth cohorts with over 33,000 family-based trio samples. We analysed polygenic scores (PGSs) for 13 mental health and neurodevelopmental conditions and their composite indices (PC1 and mean) representing general neuropsychiatric liabilities, as wel...
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