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Suicide Risk of Third-Generation Antipsychotics in Persons with Schizophrenia and Schizoaffective Disorders: A Systematic Review and Meta-Analysis

2026-02-11 psychiatry and clinical psychology Title + abstract only
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Background and HypothesisClozapine is the only antipsychotic with protective effects against suicide in schizophrenia (SCZ). Newer third-generation antipsychotics (TGA) have better tolerability and modulate serotonin, dopamine, and N-methyl-d-aspartate neurotransmission pathways implicated in suicide. We aimed to investigate the effects of TGAs on suicide in SCZ. MethodsWe searched seven databases up to December 2023 for SCZ studies that reported suicide data. The primary outcome was suicide de...

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