Back

Germline sequencing in children with cancer in Quebec: an integrated investigative approach

2026-02-10 oncology Title + abstract only
View on medRxiv
Show abstract

BackgroundThe province of Quebec has progressively implemented paired tumour-germline sequencing in paediatric oncology through two coordinated precision research programs, preceding a province-wide mainstream clinical genomics initiative. We report the prevalence, spectrum, and clinical relevance of germline findings (GFs) in children with primary extracranial cancers, integrating molecular, phenotypic, and pathological data. MethodsPatients enrolled between 2014 and 2022 underwent germline wh...

Predicted journal destinations

1
Nature Communications
483 training papers
Top 9% 10.4%
2
Cancers
57 training papers
Top 3% 7.4%
3
Clinical Cancer Research
22 training papers
Top 2% 5.6%
4
BMJ Open
553 training papers
Top 30% 5.6%
5
Frontiers in Oncology
34 training papers
Top 3% 5.6%
6
eLife
262 training papers
Top 6% 5.6%
7
PLOS ONE
1737 training papers
Top 81% 5.3%
8
British Journal of Cancer
22 training papers
Top 0.6% 5.3%
9
Genetics in Medicine
57 training papers
Top 3% 4.8%
10
Cancer Medicine
17 training papers
Top 1% 3.9%
11
JAMA Network Open
125 training papers
Top 6% 2.9%
12
Nature Genetics
72 training papers
Top 6% 2.9%
13
Scientific Reports
701 training papers
Top 83% 1.8%
14
The American Journal of Human Genetics
77 training papers
Top 6% 1.8%
15
BMC Cancer
21 training papers
Top 3% 1.8%
16
iScience
74 training papers
Top 4% 1.8%
17
Genome Medicine
56 training papers
Top 6% 1.5%
18
The Journal of Molecular Diagnostics
24 training papers
Top 1.0% 1.4%
19
eClinicalMedicine
55 training papers
Top 2% 1.3%
20
Nature
58 training papers
Top 5% 1.3%
21
Human Genetics and Genomics Advances
39 training papers
Top 6% 1.3%
22
Journal of Clinical Investigation
50 training papers
Top 4% 1.1%
23
Proceedings of the National Academy of Sciences
100 training papers
Top 16% 0.9%
24
BMC Medicine
155 training papers
Top 29% 0.9%
25
International Journal of Cancer
18 training papers
Top 1% 0.9%
26
Communications Biology
36 training papers
Top 4% 0.9%
27
Gut
17 training papers
Top 2% 0.7%
28
Communications Medicine
63 training papers
Top 9% 0.7%
29
Nature Medicine
88 training papers
Top 21% 0.7%
30
Cell Reports
25 training papers
Top 3% 0.7%