Multi-Organ Intervention State Space (MOISS): A Collision Geometry Framework for Quantifying Therapeutic Windows Across 10 Organ Systems in 301,470 ICU Patients

2026-02-09 intensive care and critical care medicine Title + abstract only

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Background: Severity scoring systems such as SOFA, NEWS2, and qSOFA effectively identify deteriorating ICU patients by aggregating physiological parameters into composite indices that trigger clinical alerts. However, these systems evaluate patient state at discrete time points and do not model the temporal dynamics of organ deterioration or the pharmacokinetic constraints that govern whether a given intervention can achieve therapeutic effect before an organ trajectory crosses an irreversible t...

Multi-Organ Intervention State Space (MOISS): A Collision Geometry Framework for Quantifying Therapeutic Windows Across 10 Organ Systems in 301,470 ICU Patients

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