Back

Lactate Cut-offs for 28-Day Mortality in Septic Shock

2026-02-10 intensive care and critical care medicine Title + abstract only
View on medRxiv
Show abstract

BackgroundEarly lactate is widely used to risk-stratify septic shock, yet clinically actionable cut-offs for 28-day mortality remain uncertain. MethodsIn a single-centre study conducted across two intensive care units, we analysed 84 adults with septic shock identified within 24 hours of intensive care unit admission. The primary endpoint was 28-day mortality. Four lactate metrics obtained during the first 24 hours were evaluated: first (admission) lactate, last lactate, peak lactate, and lacta...

Predicted journal destinations

1
PLOS ONE
1737 training papers
Top 20% 25.7%
2
Scientific Reports
701 training papers
Top 10% 13.6%
3
Critical Care Explorations
15 training papers
#1 10.4%
4
BMJ Open
553 training papers
Top 34% 4.8%
5
Frontiers in Medicine
99 training papers
Top 2% 4.5%
6
JAMA Network Open
125 training papers
Top 5% 3.2%
7
Journal of Clinical Medicine
77 training papers
Top 7% 2.2%
8
BMJ
49 training papers
Top 2% 1.5%
9
The Journal of Infectious Diseases
137 training papers
Top 9% 1.5%
10
European Respiratory Journal
44 training papers
Top 2% 1.5%
11
eLife
262 training papers
Top 29% 1.5%
12
American Journal of Respiratory and Critical Care Medicine
23 training papers
Top 1% 1.5%
13
Nature Communications
483 training papers
Top 51% 1.1%
14
BMC Infectious Diseases
110 training papers
Top 19% 1.1%
15
iScience
74 training papers
Top 9% 1.1%
16
npj Digital Medicine
85 training papers
Top 16% 1.1%
17
Frontiers in Physiology
18 training papers
Top 3% 0.8%
18
Frontiers in Immunology
140 training papers
Top 12% 0.8%
19
BMC Medicine
155 training papers
Top 30% 0.8%
20
Frontiers in Neurology
74 training papers
Top 12% 0.8%
21
PLOS Computational Biology
141 training papers
Top 16% 0.5%
22
PLOS Medicine
95 training papers
Top 29% 0.5%
23
Heliyon
57 training papers
Top 18% 0.5%
24
Journal of Biomedical Informatics
37 training papers
Top 6% 0.5%
25
Wellcome Open Research
34 training papers
Top 2% 0.5%
26
eBioMedicine
82 training papers
Top 17% 0.5%
27
Trials
24 training papers
Top 5% 0.5%