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Structural phenotypes of osteoarthritis are clinically and genetically distinct: findings from 59,539 UK Biobank participants
2026-02-10
rheumatology
Title + abstract only
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OBJECTIVESOsteoarthritis is a heterogeneous disease, with diverse structural patterns likely reflecting distinct genetic drivers. Robust, data-driven methods to identify and characterise such phenotypes are lacking. This study leveraged the UK Biobank to define machine learning-derived structural osteoarthritis phenotypes and evaluate their clinical and genetic profiles. METHODSMachine learning models were applied to knee and hip DXA scans to derive osteophyte area, minimum joint space width, a...
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