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Environment-Wide Association Study of Chemical Biomarkers and Health Outcomes in NHANES 2017-2018: Discovery, Validation, and Dose-Response Analysis

2026-02-09 occupational and environmental health Title + abstract only
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BackgroundEnvironment-wide association studies (ExWAS) offer a systematic approach to identifying chemical biomarker-health outcome associations, yet few have applied rigorous multi-stage validation. MethodsWe screened 92 chemical biomarkers against 48 health outcomes in NHANES 2017-2018 (2,796 tests across four screening rounds; not all chemicals were crossed with all outcomes). Associations passing an initial FDR screen were subjected to cross-cycle validation in NHANES 2015-2016--the primary...

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