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Deep Learning-Based Screening for POLE mutations on Histopathology Slides in Endometrial Cancer
2026-02-09
pathology
Title + abstract only
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POLE sequencing for somatic mutations (POLEmut) guides adjuvant therapy in endometrial cancer (EC), but cost and infrastructural considerations lead to limited uptake. Omission of POLE testing leads to unnecessary exposure to radiotherapy and/or chemotherapy. We developed POLARIX, a multiple instance deep learning model with attention pooling, which predicts POLE mutation status from routine hematoxylin and eosin whole-slide images (WSIs). Trained on 2,238 cases from eleven EC cohorts, POLARIX s...
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