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Early Pregnancy DNA Methylation Signatures as Predictors of Antenatal Depressive Symptoms: A longitudinal study of DNA methylation changes

2026-02-04 psychiatry and clinical psychology Title + abstract only
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BackgroundAntenatal depressive symptoms (ADS) are common and underdiagnosed, particularly in low- and middle-income countries, and are associated with adverse maternal and offspring outcomes. Current screening relies on subjective symptom reporting, limiting early identification and prevention. Epigenetic modifications, particularly DNA methylation, offer a promising avenue for objective, early biomarkers of depression risk during pregnancy. MethodsIn this nested case-control design within the ...

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