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Genetic liability to addiction underlies comorbid bipolar and substance use disorders

2026-02-05 psychiatry and clinical psychology Title + abstract only
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BackgroundBipolar disorder (BIP) frequently co-occurs with heightened substance use (SU) and substance use disorders (SUDs). Although the strong co-occurrence of these heritable traits points to shared genetic susceptibility, the extent to which there are differences in how SU and SUD overlap with BIP genetic architecture remains unclear. MethodsWe quantified the polygenic overlap between BIP and SUDs (alcohol, cannabis, opioid, and tobacco), and BIP and SU traits (drinks per week, lifetime can...

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