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GRAD: A Two-Stage Algorithm for Resolving Diagnostic Uncertainty in the Plasma p-tau217 Gray Zone
2026-02-09
neurology
Title + abstract only
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IntroductionPhosphorylated tau-217 (p-tau 217) is widely used as a plasma-based biomarker for Alzheimers Disease (AD) detection, demonstrating superior accuracy for detecting brain amyloid pathology. However, 30-50% of patients fall within an intermediate diagnostic "gray zone" where biomarker results are indeterminate, often decreasing physician confidence and requiring subsequent diagnostic workup. To address this, we developed a two-stage machine learning algorithm GRAD: Gatekeeper & Reflex ...
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