Vaccine-Elicited Antibody Responses to Influenza H3N2 Subclade K
Wang, L.; Nangle, S.; Waller-Pulido, A.; McMahan, K.; Pereira, J.; Chaudhari, J.; Barrett, L.; Bhowmik, R.; Ferrugia, K.; Ramsamooj, R.; Sordillo, E.; Simon, V.; van Bakel, H.; Mostafa, H.; Pekosz, A.; Collier, A.-r.; Barouch, D.
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Influenza H3N2 subclade K (J.2.4.1) is a genetic branch of H3N2 with 11 mutations in hemagglutinin and currently represents the dominant circulating influenza strain. We evaluated antibody responses to H3N2 subclade K before and after influenza vaccination in 46 healthy individuals. Our data show that baseline antibody responses to two H3N2 subclade K variants were lower than to other H1N1 and H3N2 strains and that antibody responses following vaccination were also less robust to the H3N2 subclade K variants. These data indicate that the H3N2 subclade K strain partially evades both prior H3N2 immunity and the current inactivated influenza vaccine.
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