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A Surgical Planning Pipeline for Human Implantable Brain-Computer Interfaces

Hadar, P. N.; Li, J.; Coughlin, B.; Munoz, W.; Hsueh, B.; Williams, Z. M.; Yee, S.; Rapalino, O.; Brandman, D.; Stavisky, S. D.; Henderson, J. M.; Willett, F. R.; Rubin, D. B.; Hochberg, L. R.; Cash, S. S.; Choi, E. Y.; Paulk, A. C.

2026-02-03 neurology
10.64898/2026.02.01.26345325 medRxiv
Show abstract

As implantable brain-computer interfaces (iBCIs) for communication and movement transition from cutting-edge research to clinical practice, a standardized approach will be required to reliably plan neurosurgeries involving complex microelectrode arrays and other neural sensors. Here, through our BrainGate study experiences, we present a replicable methodology, using open-source tools, to create interactive, personalized, 3-dimensional, virtual and physical, functional mapping models to guide iBCI surgical planning and provide intra-operative imaging displays.

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