Tracking Candida auris in Communities via Wastewater: Facility-Level Surveillance and Targeted Sequencing
Wu, J.; Wang, M.; Domakonda, K.; Schneider, R.; Short, K.; Offiong, C.; Treangen, T. J.; Ensor, K. B.; Hopkins, L.; Stadler, L.
Show abstract
Candida auris is a multidrug-resistant fungal pathogen that presents substantial challenges for healthcare facilities due to its high mortality rates among vulnerable populations. Six C. auris clades have been identified based on their susceptibility to antifungal treatment and environmental stressors. Identifying the circulating C. auris clade(s) is critical for understanding transmission and selecting a disease control strategy. To inform targeted implementation of community wastewater monitoring for C. auris, samples were collected over 34 weeks from 8 nursing homes and 6 downstream wastewater treatment plants (WWTPs). Detection rates and concentrations of C. auris DNA were significantly higher in samples from nursing homes compared to those from WWTPs. Amplicon sequencing methods were developed and applied to characterize the circulating C. auris clade in a nursing home wastewater sample. This study demonstrates the utility of wastewater monitoring as a resource-efficient approach for detecting and subtyping C. auris in vulnerable communities.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Solid evidence and liquid gold: trade-offs of processing settled solids, whole influent, or centrifuged influent for co-detecting viral, bacterial, and eukaryotic pathogens in wastewater 97%
- Extended spectrum β-lactamase and carbapenemase genes are substantially and sequentially reduced during conveyance and treatment of urban sewage 97%
- Benchmarking concentration and direct extraction methods for wastewater-based surveillance of eight human respiratory viruses: implications for rapid application to novel pathogens 97%
Similar papers in this journal
Similar papers in this journal
- Comparative analysis of culture- and ddPCR-based wastewater surveillance for carbapenem-resistant bacteria 98%
- Respiratory human adenovirus outbreak captured in wastewater surveillance 96%
- Monitoring SARS-CoV-2 in wastewater during New York City’s second wave of COVID-19: Sewershed-level trends and relationships to publicly available clinical testing data 96%
Similar papers in this journal
- High frequency, high throughput quantification of SARS-CoV-2 RNA in wastewater settled solids at eight publicly owned treatment works in Northern California shows strong association with COVID-19 incidence 96%
- Assessing multiplex tiling PCR sequencing approaches for detecting genomic variants of SARS-CoV-2 in municipal wastewater 96%
- Ecogenomics of groundwater viruses suggests niche differentiation linked to specific environmental tolerance 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.