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Dynamics of the systemic inflammatory response surrounding life events and the association with neuropsychiatric and somatic outcomes
2026-01-30
psychiatry and clinical psychology
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BackgroundAdverse life events and psychosocial stressors contribute to a range of neuropsychiatric disorders. However, the role of inflammatory dynamics around stress exposure remains unclear. Using TriNetX, a large international electronic health records database, we examined how systemic inflammatory activity and its temporal dynamics relate to subsequent risk of mental illness and somatic symptoms. MethodsWe compared 36,772 individuals with records of adverse life events and leukocytosis in ...
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