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Chronicity moderates the impact of severity on Central Executive - Default Mode Network functional interactions in Depression

2026-01-30 psychiatry and clinical psychology Title + abstract only
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Neuroimaging has revealed that major depression is underpinned by dysfunctional brain networks, with symptom variability stemming from altered interactions within and between brain regions. While the effect of depression severity is well-studied, the effect of depression duration (chronicity) is relatively neglected, despite its clinical significance. This study examined how severity, chronicity, and their interaction affect brain network connectivity and grey matter volume. Forty-six patients (...

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