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Circadian-related hypothalamic structure differs by chronotype in bipolar disorder

2026-01-30 psychiatry and clinical psychology Title + abstract only
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Background: Circadian rhythm disturbances represent a core feature of bipolar disorder (BD), with evening chronotype as a marker for poorer outcomes. We hypothesized that BD psychopathology combined with evening chronotype is associated with structural alerations in circadian-related hypothalamic regions - particularly the suprachiasmatic nucleus (SCN) - specific to BD relative to other psychiatric diagnoses. Methods: We investigated structural neuroimaging data from the UK Biobank (113 BD, 205 ...

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