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PAGAN predicts digenic interactions by generalizing single-gene representations in biological networks
2026-01-29
genetic and genomic medicine
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Digenic alterations can produce phenotypes such as synthetic lethality or digenic disease that are not observed upon individual gene perturbation, often by disrupting compensatory or redundant biological mechanisms. We hypothesized that gene pairs underlying such phenotypes share, when considered jointly, biological network properties analogous to those of essential genes or monogenic Mendelian disease genes. To test this hypothesis, we developed PAGAN, a graph representation learning framework ...
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