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Transdiagnostic Reductions in Glymphatic-Related Perivascular Diffusion Across Psychiatric Disorders: A Systematic Review and Meta-analysis

2026-02-03 psychiatry and clinical psychology Title + abstract only
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BackgroundImpaired glymphatic clearance, the perivascular system supporting cerebrospinal and interstitial fluid exchange, has been implicated in neurodegenerative and psychiatric disorders. Diffusion tensor imaging along the perivascular space (DTI-ALPS) provides a non-invasive proxy for glymphatic-related processes, yet its role in psychiatric conditions remains uncertain. MethodsFollowing PRISMA guidelines, we systematically searched PubMed, PsycNET, and Embase for articles published up to S...

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