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Pathogenic HFE Variants and Evaluation for Hemochromatosis in Patients with Early-onset Atrial Fibrillation

2026-02-01 cardiovascular medicine Title + abstract only
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BackgroundGenetic testing is now recommended for select patients with early-onset atrial fibrillation (AF). Hemochromatosis is an autosomal recessive syndrome that occurs in patients who carry two pathogenic or likely-pathogenic (P/LP) variants in HFE. HFE is included on some genetic testing panels used for patients with AF. Hemochromatosis causes cardiomyopathy due to iron overload in the ventricle; however, it is unknown whether AF can be an early manifestation that is identified by genetic te...

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