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A Modularized Stretchable Microneedle Array for Minimally Invasive and Efficient Drug Delivery

Zhang, S.; Chang, Y.; FNU, Y.; Du, K.; Liu, R.

2026-01-24 bioengineering
10.64898/2026.01.22.701215 bioRxiv
Show abstract

A novel Modularized Stretchable Microneedle Array (MSMA) is developed for minimally invasive and efficient drug delivery. By applying a modular design, the MSMA can be highly customized, offering versatility for different therapeutic applications. Its high stretchability allows for simultaneous stretching of both the microneedle and the skin, enhancing the penetration rate. Evaluations using tissue-mimicking materials and porcine skin demonstrated significant improvements in penetration efficiency and reduced residual strain. The MSMA achieved penetration rates of up to 89% on porcine skin under a minimum push-down distance of 2 mm. Moreover, the MSMAs ability to stretch and release in synchronization with the skin significantly reduces residual strain. This innovative platform promises reduced pain and discomfort, representing a substantial advancement in transdermal drug delivery technology.

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