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Evaluating the use of hierarchical composite endpoints in pediatric cancer supportive care clinical trials: Illustrative examples from two multi-center phase-III randomized clinical trials
2026-01-23
oncology
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PURPOSEPediatric supportive care trials frequently rely on analyses of multiple clinically relevant outcomes, posing challenges for overall trial interpretation. Hierarchical composite endpoints (HCEs) rank relevant outcomes by prespecified clinical importance and offer potential advantages such as harmonizing trial conclusions. METHODSWe reanalyzed two randomized supportive care trials utilizing post-hoc HCE, each conducted through the Childrens Oncology Group. ACCL0934 evaluated levofloxacin ...
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