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Substance use disorders exhibit unique and disorder specific genetic associations with externalizing and internalizing psychopathology

2026-01-22 genetic and genomic medicine Title + abstract only
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Background and AimsSubstance use disorders (SUDs) are heritable and share genetic variance with externalizing and internalizing psychopathology. Although recent gene identification efforts have demonstrated the value of modeling the shared genetic architecture among SUDs and externalizing, most research has thus far failed to account for overlap with internalizing. In this study, we aim to characterize the genetic relationships of both externalizing and internalizing with SUDs. Design and setti...

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