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The Course of Relapse Following Antipsychotic Discontinuation in Schizophrenia: A Test of the Antipsychotic Withdrawal Syndrome Hypothesis of Relapse

2026-01-22 psychiatry and clinical psychology Title + abstract only
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BackgroundAntipsychotics are central to relapse prevention in schizophrenia, but longer-term use is associated with adverse effects that often prompt dose reduction or discontinuation. Although relapse risk increases after discontinuation, the nature of relapse remains unclear. Specifically, it is uncertain whether relapse reflects re-emergence of underlying illness or pharmacological withdrawal. MethodsWe analysed longitudinal symptom data (Positive and Negative Syndrome Scale; PANSS) from 417...

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