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Comparing family history indicators and polygenic scores in depressive disorder
2026-01-22
psychiatry and clinical psychology
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BackgroundGenetic liability of depressive disorder can be captured by psychopathology in relatives (family history). Various methods summarize family history in a single score, differing in included information as well as underlying model. We systematically compared the performance of family history indicators, including promising new indicators based on the liability threshold model, in predicting depressive disorder. MethodsWe calculated selected family history indicators for depression (dich...
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