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Towards Culture-Free Sequencing of Mycobacterium tuberculosis: Evaluating New Targeted and Whole-Genome Approaches for Genotyping and Drug Resistance Profiling

2026-01-20 infectious diseases Title + abstract only
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BackgroundThe effectiveness of current drug-resistant tuberculosis (DR-TB) regimens is limited by the absence of rapid diagnostics that comprehensively predict resistance to included drugs. Next-generation sequencing (NGS), through culture-free targeted sequencing (tNGS) and culture-based whole-genome sequencing (cWGS) of the Mycobacterium tuberculosis complex (MTBC), offers a powerful framework for precision diagnosis, surveillance, and trial applications. We evaluated two novel assays enabling...

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