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Grey Matter Iron and Neuromelanin in Psychosis: A Systematic Review and Meta-Analysis of MRI Studies

2026-01-17 psychiatry and clinical psychology Title + abstract only
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ObjectiveThe pathophysiology of psychosis remains unclear. Preclinical, postmortem, and imaging evidence implicates iron and neuromelanin, but the consistency and magnitude of effects are uncertain. We aimed to characterise brain iron and neuromelanin alterations in psychosis through a systematic review and meta-analysis of iron-sensitive MRI and neuromelanin-sensitive MRI (NM-MRI) studies. MethodsWe searched EMBASE, PubMed, and PsycINFO from inception to October 31, 2025, for case-control stud...

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