Clinical and Laboratory Characteristics of Adolescents and Young Adults with Sickle Cell Disease at Steady State in Uganda
Ssekandi, A. M.; Namazzi, R.; Muwonge, H.; Kalysebula, R.; Munabi, I. G.; Sekaggya-Wiltshere, C.; Namaganda, A.; Kimuli, I.; Akugizibwe, R.; Kasujja, H.; Mukunya, D.; Ndeezi, G.; Kiguli, S.
Show abstract
Sickle cell disease (SCD) is associated with chronic systemic morbidity that extends beyond acute crises. However, data describing the clinical and laboratory adolescents and young adults with SCD at steady state in sub-Saharan Africa are limited. We described clinical and laboratory characteristics of adolescents and young adults with SCD at steady state in Uganda. We conducted a hospital-based cross-sectional study of 60 adolescents and young adults with SCD in steady state at Mulago National Referral Hospital. Descriptive statistics were used to summarize participant characteristics and medication use. The mean age was 16.5 {+/-} 3.3 years, and 34 (56.7%) participants were female. Mean hemoglobin was 9.1 {+/-} 2.2 g/dl. Mean systolic and diastolic blood pressures were 107.9 {+/-} 15.5 mmHg and 60.3 {+/-} 12.6 mmHg, respectively; mean heart rate was 89.5 {+/-} 15.5 beats/min. Fifty-two (86.7%) participants reported using hydroxyurea. These observations show that adolescents and young adults with SCD at steady state exhibit hematologic abnormalities and distinctive hemodynamic profiles that underscore substantial chronic subclinical abnormalities that extend beyond acute complications.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Comparison of haemoglobin concentration measurements using HemoCue-301 and Sysmex XN-Series 1500: a survey among anaemic Gambian infants aged 6-12 months 95%
- Severe anaemia complicating HIV in Malawi; multiple co-existing aetiologies are associated with high mortality. 94%
- Feasibility of collecting and processing of COVID-19 convalescent plasma for treatment of COVID-19 in Uganda 94%
Similar papers in this journal
- Use of Point-of-care Haemoglobin Tests to Diagnose Childhood Anaemia in Low-and Middle-Income Countries: A Systematic Review 92%
- Factors associated with the incidence rate of HIV viral rebound among children and adults receiving antiretroviral therapy in Malawi using the Laboratory Management information System: 2011-2020 89%
- Interest of seroprevalence surveys for the epidemiological surveillance of the SARS-CoV-2 pandemic in African populations: insights from the ARIACOV Project in Benin 89%
Similar papers in this journal
- The prevalence of hepatitis C virus (HCV) infection in β-thalassemia patients in Pakistan: a systematic review and meta-analysis 90%
- Maternal Factors Promoting Normal Linear Growth of Children from Impoverished Rwandan Households 88%
- The association of child marriage with morbidities and mortality among children under 5 years in Afghanistan: Findings from a national survey 88%
Similar papers in this journal
- Loss of Factor H family proteins associates with meningococcal disease severity 91%
- Inflammation and autoimmunity are interrelated in patients with sickle cell disease at a steady-state condition: implications for vaso-occlusive crisis, pain, and sensory sensitivity 91%
- Immune-Based Prediction of COVID-19 Severity and Chronicity Decoded Using Machine Learning 90%
Similar papers in this journal
- Blood transfusion in care of patients with Visceral Leishmaniasis: a review of practices in therapeutic efficacy studies 91%
- MOSQUITO TRANSMISSION AND HUMAN HEPATOCYTE INFECTIONS WITH Plasmodium ovale curtisi AND P. ovale wallikeri 87%
- The seroprevalence and trends of SARS-CoV-2 in Delhi, India: A repeated population-based seroepidemiological study 86%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.