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Exploring reward learning disruptions as a possible mechanism underlying neuropsychiatric symptoms in Parkinson's disease

2026-01-16 psychiatry and clinical psychology Title + abstract only
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BackgroundThe causes of neuropsychiatric symptoms in Parkinsons disease (PD) remain ill-defined. Disruptions in dopamine-dependent reward learning, a consequence of midbrain dopamine loss, potentially represent a mechanism that could underlie the neuropsychiatric symptoms of apathy, depression, and impulsivity, all of which have been proposed to reflect aberrant goal-directed behaviour. However no large-scale investigation that jointly considers these symptoms in PD has ever been undertaken. We ...

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