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Distinct baseline functional profiles of peanut-reactive T cells associate with sustained unresponsiveness after oral immunotherapy

2026-01-16 allergy and immunology Title + abstract only
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BackgroundPeanut allergies continuously present urging public health challenges. Oral immunotherapy (OIT) is an important treatment option for peanut allergies, but its effectiveness varies, in terms of inducing desensitization (DS) or achieving long-term sustained unresponsiveness (SU). Identifying biomarkers to predict OIT outcomes is thus of great translational interests. MethodsWe thoroughly analyzed data from the POISED trial and our in-house OPIA trial, with a particular focus on the pean...

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