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Dynamical Behavior Analysis of 2-control Strategies on Tuberculosis Model

Nayeem, J.; Salek, M. A.; Nayeem, J.; Hossain, M. S.; Kabir, M. H.

2026-01-15 epidemiology
10.64898/2026.01.13.26343993 medRxiv
Show abstract

To characterize tuberculosis transmission and assess the impact of important interventions, a data-driven SEITR TB model is created. The potential for disease persistence has been calculated using the basic reproduction number. To determine the factors most significantly affecting the spread of tuberculosis, stability and sensitivity analyses are conducted. Strengthened treatment measures and optimized distancing significantly lower infection levels, according to numerical simulations. The Least Squares Fitting technique is used to validate real epidemiological data with a model solution. And the results emphasize that the best combinations of social distancing and treatment not only reduce the number of infections but also provide a cost-effective strategy for public health planning. Additionally, two numerical techniques, namely Pearson correlation and Partial Rank Correlation Coefficients (PRCC), are utilized to assess the sensitivity of model parameters. It is noted that the outcomes of these two methods are in agreeable comparison with one another regarding sensitivity analysis.

Published in PLOS Global Public Health (predicted rank #11) · training set

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