Back

A Phenotypic Paradigm for Cerebral Palsy Genetics

2026-01-18 genetic and genomic medicine Title + abstract only
View on medRxiv
Show abstract

Disease-causing genetic variants can be found in a subset of individuals with cerebral palsy (CP), with variants deemed causal of CP having been published for at least 515 genes. We develop a statistical approach that treats CP as a phenotypic feature for which some genetic disorders confer an increased risk. Based on comprehensive literature curation we show that the null hypothesis of no CP association can be rejected for only 89 of the 515 genes. We applied these findings to the analysis of a...

Predicted journal destinations