Isothermal Detection of Influenza D using RT-LAMP
dos Santos, C. A.; Li, J.; van Diemen, P. M.; McMahon, A.; Mollett, B. C.; Ramsay, A. M.; Maina, M. M.; James, J.; Everett, H. E.; Daly, J. M.; Robb, N. C.
Show abstract
The Orthomyxoviridae family includes influenza D virus (IDV), an emerging pathogen primarily affecting cattle and swine, with evidence of cross-species transmission and potential zoonotic risk. Although active human infections have yet to been confirmed, high seroprevalence in cattle-exposed populations highlights the need for continued surveillance. Here, a rapid, field-deployable RT-LAMP assay for IDV detection was developed and validated, with 99.2% specificity and sensitivity ranging from 95.6% (Cq < 30) to 81.8% (Cq < 40). This method offers a cost-effective, accessible alternative to RT-qPCR, enabling improved monitoring of IDV, and reinforcing preparedness for emerging influenza threats.
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