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FUSION: A fast and uniform processing framework for whole-brain optical scattering tomography images

CHEN, C.; GU, P.; VILLIGER, M.; URIBE-PATARROYO, N.; BOUMA, B.; REN, J.

2026-01-07 bioengineering
10.64898/2026.01.06.698063 bioRxiv
Show abstract

Coherent scattering imaging has seen substantial development in clinical ophthalmology and endoscopic microscopy owing to its high throughput, large dynamic range, and capability for label-free imaging. However, limited optical penetration has constrained its application to whole-organ imaging studies. Here, we propose a high-throughput coherent scattering imaging system assisted by tissue clearing, termed fuCAST, which enables whole-brain white-matter imaging. In parallel, we develop a high-throughput image reconstruction and uniform stitching platform, FUSION, specifically tailored for fuCAST datasets.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.