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Antibodies elicited by the 2025-2026 influenza vaccine in humans

Liu, J.; Li, S. H.; Ye, N.; Griffiths, T.; Drapeau, E. M.; Atkinson, R.; Collman, R.; Hensley, S.

2026-01-06 infectious diseases
10.64898/2026.01.05.26343449 medRxiv
Show abstract

A new H3N2 variant (named subclade K) possesses several key hemagglutinin substitutions and is circulating widely during the 2025-2026 influenza season. In this report, we completed experiments to determine if the 2025-2026 seasonal influenza vaccine elicits antibodies in humans that recognize this variant. We find that H3N2 subclade K viruses are antigenically advanced; however, the 2025-2026 seasonal influenza vaccine elicited antibodies in many individuals that efficiently recognized these viruses. Thus, the current seasonal influenza vaccine will likely be somewhat effective at preventing H3N2 subclade K virus infections.

Matching journals

The top 6 journals account for 50% of the predicted probability mass.

1
Influenza and Other Respiratory Viruses
○ 46 papers in training set
Top 0.1%
17.7%
Similar papers in this journal
2
New England Journal of Medicine
● 52 papers in training set
Top 0.1%
11.4%
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3
Nature Communications
○ 5641 papers in training set
Top 22%
7.5%
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4
Nature Medicine
○ 125 papers in training set
Top 0.2%
7.5%
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5
Nature
○ 645 papers in training set
Top 3%
5.2%
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6
eBioMedicine
○ 183 papers in training set
Top 0.7%
4.1%
50% of probability mass above
7
mBio
● 833 papers in training set
Top 5%
3.9%
8
Science Translational Medicine
● 127 papers in training set
Top 0.8%
3.1%
9
Clinical Infectious Diseases
◐ 235 papers in training set
Top 1%
3.1%
10
JAMA
● 18 papers in training set
Top 0.1%
2.5%
11
The Journal of Infectious Diseases
◐ 202 papers in training set
Top 2%
2.3%
12
Med
○ 39 papers in training set
Top 0.2%
2.3%
13
Journal of Virology
● 499 papers in training set
Top 2%
1.9%
14
The Lancet Infectious Diseases
○ 73 papers in training set
Top 0.6%
1.8%
15
Open Forum Infectious Diseases
◐ 142 papers in training set
Top 2%
1.6%
16
JCI Insight
● 277 papers in training set
Top 5%
1.4%
17
Vaccine
○ 203 papers in training set
Top 1%
1.4%
18
JAMA Network Open
● 130 papers in training set
Top 3%
1.3%
19
Emerging Infectious Diseases
● 105 papers in training set
Top 1%
1.1%
20
Proceedings of the National Academy of Sciences
● 2444 papers in training set
Top 36%
1.1%
21
Cell Reports
○ 1498 papers in training set
Top 25%
1.0%
22
Nature Microbiology
○ 155 papers in training set
Top 3%
1.0%
23
Emerging Microbes & Infections
○ 74 papers in training set
Top 1%
0.9%
24
npj Vaccines
○ 67 papers in training set
Top 0.8%
0.9%
25
Journal of Clinical Investigation
● 179 papers in training set
Top 5%
0.9%
26
Scientific Reports
○ 3612 papers in training set
Top 75%
0.8%
27
Cell Reports Medicine
○ 153 papers in training set
Top 5%
0.8%
28
iScience
○ 1154 papers in training set
Top 43%
0.6%
29
Journal of Travel Medicine
◐ 18 papers in training set
Top 0.2%
0.6%

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.